Anales de Osteología y Osteoporosis
Número 15, 15 de Marzo de 2008
Contenido adicional
Anales
Noticias
- OSTEOLOGÍA : - OSTEOPOROSIS EN HOMBRES : - Los médicos emiten una directriz sobre la exploración de la osteoporosis en hombres
El American College of Physicians (ACP) ha emitido una nueva directriz clínica sobre la exploración de la osteoporosis en hombres, que señala que las tasas de osteoporosis entre hombres ...
- BONE REPAIR : - Influence of short-term adenoviral vector and prolonged lentiviral vector mediated bone morphogenetic protein-2 expression on the quality of bone repair in a rat femoral defect model
The objective of this study was to compare the efficacy of adenoviral and lentiviral regional gene therapy in a rat critical sized femoral defect model. The healing rates and quality of bone repair ...
- OSTEOLOGY : -Continuous PGE2 leads to net bone loss while intermittent PGE2 leads to net bone gain in lumbar vertebral bodies of adult female rats
The present study examined the effects of continuous and intermittent PGE2 administration on the cancellous and cortical bone of lumbar vertebral bodies (LVB) in female rats. Six-month-old ...
- OSTEOLOGY : - Cell viability, osteoblast differentiation, and gene expression are altered in human osteoblasts from hypertrophic fracture non-unions
Recent studies have provided evidence that the number and proliferation capacity of bone marrow-derived mesenchymal stem cells, as well as the number of osteoprogenitor cells are reduced in patients ...
- OSTEOLOGY : - Ubc9 promotes the stability of Smad4 and the nuclear accumulation of Smad1 in osteoblast-like Saos-2 cells
Bone morphogenetic proteins (BMPs) play important roles in osteoblast differentiation and maturation. In mammals, the BMP-induced receptor-regulated Smads form complexes with Smad4. These complexes ...
- OSTEOLOGY : - Molecular requirements for induction of CTGF expression by TGF-β1 in primary osteoblasts
Connective tissue growth factor (CTGF/CCN2) is a cysteine rich, extracellular matrix protein that acts as an anabolic growth factor to regulate osteoblast differentiation and function. In ...
- OSTEOLOGY : - Circadian mechanisms in murine and human bone marrow mesenchymal stem cells following dexamethasone exposure
A core group of regulatory factors control circadian rhythms in mammalian cells. While the suprachiasmatic nucleus in the brain serves as the central core circadian oscillator, circadian clocks also ...
- OSTEOLOGY: Visualizing mineral binding and uptake of bisphosphonate by osteoclasts and non-resorbing cells
Bisphosphonates (BPs) target bone due to their high affinity for calcium ions. During osteoclastic resorption, these drugs are released from the acidified bone surface and taken up by osteoclasts, ...
- MUSCLE & BONE : - Sex-specific developmental changes in muscle size and bone geometry at the femoral shaft
Introduction When expressed as a percentage of the average result in young adults, bone mineral content lags behind bone length before puberty. Even though this observation has led to speculation ...
- OSTEOLOGÍA: La densidad ósea dependería de varios genes
Dos estudios difundidos el martes identifican varias mutaciones genéticas que modificarían el riesgo de desarrollar osteoporosis y sufrir fracturas. Según publica The New England Journal of ...
- WOMEN HEALTH : OSTEOLOGY : Genetic variation in the PTH pathway and bone phenotypes in elderly women : Evaluation of PTH, PTHLH, PTHR1 and PTHR2 genes
Introduction Parathyroid hormone (PTH) is a key regulator of calcium metabolism. Parathyroid hormone-like hormone (PTHrP) contributes to skeletal development through regulation of chondrocyte ...
- OSTEOLOGY : Jump starting skeletal health: A 4-year longitudinal study assessing the effects of jumping on skeletal development in pre and circum pubertal children
Evidence suggests bone mineral increases attributable to exercise training prior to puberty may confer a significant advantage into adulthood. However, there is a dearth of supportive prospective ...
- OSTEOLOGY : Effects of low-dose parathyroid hormone on bone mass, turnover, and ectopic osteoinduction in a rat model for chronic alcohol abuse
Parathyroid hormone (PTH) is used clinically in osteoporotic patients to increase bone mass by enhancing bone formation. PTH therapy is not uniformly effective at all skeletal sites and “life-style” ...
- EXPERIMENTAL OSTEOLOGY : Role of genetic background in determining phenotypic severity throughout postnatal development and at peak bone mass in Col1a2 deficient mice (oim)
Osteogenesis imperfecta (OI) is a genetically and clinically heterogeneous disease characterized by extreme bone fragility. Although fracture numbers tend to decrease post-puberty, OI patients can ...
- OSTEOLOGY : Dkk1-induced inhibition of Wnt signaling in osteoblast differentiation is an underlying mechanism of bone loss in multiple myeloma
Expression of the Wnt signaling inhibitor, DKK1 by multiple myeloma cells is correlated with lytic bone disease in multiple myeloma. However, the mechanism(s) by which DKK1 contributes to this ...
