Los trastornos epigenéticos se han asociado con el desarrollo de distintos tipos de leucemia y, por lo tanto, los estudios epigenéticos se perfilan como una línea de investigación con futuro en este ...

Un estudio dirigido por Pier Paolo Pandolfi describe el papel de la proteína de la leucemia promielocítica en el mantenimiento de las células madre hematopoyéticas y presenta un nuevo enfoque ...

El complejo MRE-11, una vía alternativa de reparación del ADN, presente en tumores como los linfomas, se ha asociado con una mayor quimiosensibilidad de los linfomas, según los estudios llevados a ...

La secuenciación del genoma de la leucemia linfática crónica, prevista por el Consorcio Internacional del Genoma del Cáncer, no será rápida, por limitaciones tecnológicas y económicas, ha advertido ...

Acute myeloid leukemia (AML) involves the immortalization of immature myeloid progenitors and is a heterogeneous disease. Current clinical practice separates AML into low-, intermediate-, and ...

Investigadores del Instituto Nacional del Cáncer, en Estados Unidos, han descubierto que seis años antes de la manifestación de la leucemia linfocítica ya son detectables glóbulos blancos anormales. ...

She had been living with multiple myeloma for more than 7 years before she showed up in our intensive care unit (ICU). It had not been easy, but she had beaten the median survival time by a factor ...

Background Despite best current therapy, up to 20% of pediatric patients with acute lymphoblastic leukemia (ALL) have a relapse. Recent genomewide analyses have identified a high frequency of DNA ...

Background The main features of severe congenital neutropenia are the onset of severe bacterial infections early in life, a paucity of mature neutrophils, and an increased risk of leukemia. In many ...

In 1956, Rolf Kostmann, a Swedish pediatrician, described an autosomal recessive disorder that he called infantile genetic agranulocytosis — which is now called severe congenital neutropenia. The ...

Background The myeloproliferative disorders are clonal disorders with frequent somatic gain-of-function alterations affecting tyrosine kinases. In these diseases, there is an increase in DNA damage ...

Un grupo de investigadores informó que se producirían más casos de los cánceres sanguíneos denominados linfoma no Hodgkin (NHL) entre las personas con diabetes que entre aquellas sin la enfermedad ...

Infants and adults with the blood cancer mixed-lineage leukemia (MLL) typically have a poor prognosis, and most infants die before their first birthdays. Although there are varying causes of MLL, ...

To the Editor: The recent "heparin scandal" resulted from the use of contaminated heparin that caused serious adverse events including death.1 The contaminant was identified as synthetically ...

Abstract Cyclic neutropenia (CN) has been well documented in humans and the gray collie. A recent model of the architecture and dynamics of hematopoiesis has been used to provide insights into the ...