Objective The posttranslational regulation of GTP cyclohydrolase I (GCH-1), the rate-limiting enzyme for tetrahydrobiopterin (BH4) synthesis, remains elusive. Here, we identified specific ...

Metalloproteins catalyse some of the most complex and important processes in nature, such as photosynthesis and water oxidation. An ultimate test of our knowledge of how metalloproteins work is to ...

Almost half of all enzymes must associate with a particular metal to function. An ambition is to understand why each metal–protein partnership arose and how it is maintained. Metal availability ...